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The antitumor activity of a new antibiotic, kazusamycin, against various murine tumors was studied by various treatment schedules. Single, intermittent, and successive injections of the antibiotic were almost equally effective against Ehrlich carcinoma, IMC carcinoma and sarcoma 180 tumor, but successive injections showed more efficacy than the other schedules against Meth A fibrosarcoma and Lewis lung carcinoma. Interestingly, there was no clear dose response for the efficacy of kazusamycin on murine tumors. When HeLa cells were exposed to kazusamycin for 72 hours in vitro, the IC50 value was about 1 ng/ml, however the cytotoxicity of the antibiotic depended on the incubation time.
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
June 1987,
The Journal of antibiotics,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
June 1982,
The Journal of antibiotics,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
April 1977,
Gan,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
March 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
December 1981,
The Journal of antibiotics,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
July 1989,
Investigational new drugs,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
May 1964,
Cancer chemotherapy reports,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
August 1989,
The Journal of antibiotics,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
April 1989,
The Journal of antibiotics,
K Komiyama, and
K Okada, and
Y Hirokawa, and
K Masuda, and
S Tomisaka, and
I Umezawa
June 1986,
The Journal of antibiotics,
