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Changes in plasma GH levels in response to an intravenous bolus injection of 200 micrograms GHRH-44 or 0.1 U/kg body weight regular insulin were examined in normal men who were pre-treated with 200 micrograms GHRH-44 or 0.1 U/kg body weight regular insulin 120 min in advance. The prior bolus injection of GHRH-44 inhibited the plasma GH response to the subsequent administration of GHRH-44 whereas the plasma GH response to the subsequent injection of insulin was not influenced by the prior administration of GHRH-44. The prior administration of insulin attenuated the plasma GH response to the subsequently given GHRH-44. These results suggest that desensitization of GHRH receptors in somatotrophs and/or somatostatin hypersecretion induced by increase in plasma GH levels following the prior GHRH-44 administration may be involved in the mechanism by which the prior GHRH-44 administration or insulin-induced hypoglycemia suppressed plasma GH responses to the following GHRH-44 administration. Sudden suppression of somatostatin secretion, which causes rebound of GH secretion, may occur in insulin-induced hypoglycemia.
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
December 1987,
The Journal of clinical endocrinology and metabolism,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
January 1996,
European journal of endocrinology,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
January 1993,
The Journal of clinical endocrinology and metabolism,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
February 1992,
Acta endocrinologica,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
December 2004,
The Journal of endocrinology,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
February 1979,
International journal of clinical pharmacology and biopharmacy,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
May 1993,
Journal of endocrinological investigation,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
January 1982,
The Journal of clinical endocrinology and metabolism,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
February 1998,
Journal of endocrinological investigation,
T Shibasaki, and
M Hotta, and
A Masuda, and
T Imaki, and
N Obara, and
H Demura, and
N Ling, and
K Shizume
January 1987,
The Tohoku journal of experimental medicine,
