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The cross-reactivity of human placental microsomal NADPH-cytochrome c reductase antiserum, REDFBIV, against the endometrial reductase alone and as a component of the endometrial aromatase was investigated. Human endometrial particulate fractions were incubated with various amounts of REDFBIV for 1 h at 4 degrees C and both enzyme activities were measured at the end of incubation. The extent of inhibition of these endometrial enzymes was compared with the ability of this antiserum to inhibit the placental microsomal reductase and aromatase activities. The antiserum effectively inhibited the activities of both enzymes in both tissues in a dose dependent manner with aromatase activity inhibited to a greater extent than reductase activity. These results indicate the antiserum to the placental microsomal NADPH-cytochrome c reductase component of aromatase recognizes the reductase component of the aromatase enzyme system in endometrium.
L Tseng, and
F L Bellino
August 1971,
Biochemical pharmacology,
L Tseng, and
F L Bellino
February 2001,
Molecular and cellular endocrinology,
L Tseng, and
F L Bellino
March 1986,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
L Tseng, and
F L Bellino
January 1980,
Biochemical pharmacology,
L Tseng, and
F L Bellino
November 1974,
Archives of biochemistry and biophysics,
L Tseng, and
F L Bellino
November 1992,
The Journal of steroid biochemistry and molecular biology,
L Tseng, and
F L Bellino
April 1966,
Bollettino della Societa italiana di biologia sperimentale,
L Tseng, and
F L Bellino
January 1973,
Annals of the New York Academy of Sciences,
L Tseng, and
F L Bellino
January 1989,
Biochemical pharmacology,
L Tseng, and
F L Bellino
February 1999,
European journal of cancer (Oxford, England : 1990),
