Leukocyte adherence inhibition, natural killer cell activity, gamma-interferon production capacity and phytohemagglutinin response in patients treated with recombinant leukocyte A interferon. 1985

B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek

10 patients with disseminated colorectal cancer were treated either chronically or cyclically with human recombinant leukocyte A interferon (IFl-rA) for 3 months. During this period, leukocyte adherence inhibition (LAI), natural killer (NK) cell activity, concanavalin A-induced gamma-interferon production capacity (GIPCA) and phytohemagglutinin response were sequentially monitored. In both chronically and cyclically treated patients, IFl-rA therapy led to a 'short-lived' augmentation of NK cell activity. In the chronically treated patients, there was a further depression in the NK cell activity during the course of therapy. The outcome of LAI remained unaltered irrespective of the mode of IFl-rA therapy. There was an inverse correlation between GIPCA and phytohemagglutinin response.

UI MeSH Term Description Entries
D007370 Interferon Type I Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA). Interferons Type I,Type I Interferon,Type I Interferons,Interferon, Type I,Interferons, Type I
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D007694 Killer Cells, Natural Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D007957 Leukocyte Adherence Inhibition Test Test for cell-mediated antitumor immunity and related serum blocking factors based on the finding that leukocytes from cancer patients, but not from controls, when mixed in vitro with antigenic extracts of tumors of the same histological type, undergo a diminution in their normal adherence to glass surfaces. Sera from tumor-bearing patients block the LAI reaction of their own leukocytes or those of other patients with the same type of tumor. LAI Test,LAI Tests,Test, LAI,Tests, LAI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010835 Phytohemagglutinins Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture. Kidney Bean Lectin,Kidney Bean Lectins,Lectins, Kidney Bean,Phaseolus vulgaris Lectin,Phaseolus vulgaris Lectins,Phytohemagglutinin,Hemagglutinins, Plant,Lectin, Kidney Bean,Lectin, Phaseolus vulgaris,Lectins, Phaseolus vulgaris,Plant Hemagglutinins
D012004 Rectal Neoplasms Tumors or cancer of the RECTUM. Cancer of Rectum,Rectal Cancer,Rectal Tumors,Cancer of the Rectum,Neoplasms, Rectal,Rectum Cancer,Rectum Neoplasms,Cancer, Rectal,Cancer, Rectum,Neoplasm, Rectal,Neoplasm, Rectum,Rectal Cancers,Rectal Neoplasm,Rectal Tumor,Rectum Cancers,Rectum Neoplasm,Tumor, Rectal
D002860 Chromium Radioisotopes Unstable isotopes of chromium that decay or disintegrate emitting radiation. Cr atoms with atomic weights of 46-49, 51, 55, and 56 are radioactive chromium isotopes. Radioisotopes, Chromium
D003110 Colonic Neoplasms Tumors or cancer of the COLON. Cancer of Colon,Colon Adenocarcinoma,Colon Cancer,Cancer of the Colon,Colon Neoplasms,Colonic Cancer,Neoplasms, Colonic,Adenocarcinoma, Colon,Adenocarcinomas, Colon,Cancer, Colon,Cancer, Colonic,Cancers, Colon,Cancers, Colonic,Colon Adenocarcinomas,Colon Cancers,Colon Neoplasm,Colonic Cancers,Colonic Neoplasm,Neoplasm, Colon,Neoplasm, Colonic,Neoplasms, Colon

Related Publications

B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
March 1983, Biochemical and biophysical research communications,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
November 1986, Hawaii medical journal,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
November 1985, Clinical immunology and immunopathology,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
August 1987, Gastroenterologia Japonica,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
July 1983, Journal of the neurological sciences,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
November 1983, Journal of the National Cancer Institute,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
January 1986, Archives of dermatological research,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
April 2024, European journal of immunology,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
January 1983, Journal of biological response modifiers,
B Tank, and A M Bijma, and R L Marquet, and A M Eggermont, and W Weimar, and J Jeekel, and D L Westbroek
August 1991, British journal of haematology,
Copied contents to your clipboard!