-transparent.png){kind=logo}
We examined the effect of acetaminophen and the structural analogues 2,6-dimethylacetaminophen, 3,5-dimethylacetaminophen, and N-acetyl-p-benzoquinone imine on human platelet aggregation, 14C-serotonin secretion, and thromboxane B2 synthesis. Preincubation with 1 mM acetaminophen for 2 min completely inhibited arachidonic acid- and collagen-stimulated platelet aggregation. Thromboxane B2 production and 14C-serotonin secretion by arachidonic acid-stimulated platelets also were completely inhibited. Preincubation of platelets with 1 mM 3,5-dimethylacetaminophen inhibited collagen and arachidonic acid-induced aggregation and arachidonic acid-stimulated thromboxane B2 synthesis, while treatment with 2,6-dimethylacetaminophen did not inhibit aggregation and blocked thromboxane B2 formation to a much lesser degree. Preincubation with 1 mM N-acetyl-p-benzoquinone imine inhibited arachidonic acid-induced aggregation and 14C-serotonin secretion but had no effect on arachidonic acid-induced thromboxane B2 formation and collagen-induced platelet aggregation.
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
June 1991,
Thrombosis research,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
March 1998,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
August 1999,
Journal of ethnopharmacology,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
September 1989,
Atherosclerosis,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
January 1980,
Advances in prostaglandin and thromboxane research,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
February 2008,
The Journal of antimicrobial chemotherapy,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
January 1987,
Haemostasis,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
January 1982,
Cardiologia (Rome, Italy),
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
January 1980,
Thrombosis research,
R I Shorr, and
K J Kao, and
S V Pizzo, and
E J Rauckman, and
G M Rosen
January 1990,
Archives internationales de pharmacodynamie et de therapie,
