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Oral UFT was given to patients with genital carcinoma prior to surgery. 5-FU, FT and uracil levels in the tumor site were then measured in the surgical specimens obtained. Simultaneous estimates of tissues and plasma 5-FU indicated that the amount of drug in the tumor site (0.227 +/- 0.117 micrograms/g wet weight) had a 6.3-fold increase in concentration compared with that in normal tissues (0.036 +/- 0.019 micrograms/g wet weight) and was approximately 13.4 times that of the peripheral circulation (0.017 +/- 0.007 micrograms/ml). The rate of increase in concentration of tissue 5-FU rose especially in carcinoma of the cervix (0.394 +/- 0.215 micrograms/g), corpus uteri (0.116 +/- 0.042 micrograms/g) and ovary (0.171 +/- 0.047 micrograms/g). In the case of carcinoma of the cervix, the concentration of 5-FU in the tumor site was found to be about 14.1 times higher in invasive carcinoma than in carcinoma in situ. 5-FU concentration in the tumor site showed a still higher level compared with normal tissue after the drug was administered, suggesting an accumulation of 5-FU within the tumor.
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
July 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
August 1983,
Gan to kagaku ryoho. Cancer & chemotherapy,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
November 1986,
Gan no rinsho. Japan journal of cancer clinics,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
August 1984,
Nihon Sanka Fujinka Gakkai zasshi,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
February 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
October 1983,
Gan to kagaku ryoho. Cancer & chemotherapy,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
November 1992,
Gan to kagaku ryoho. Cancer & chemotherapy,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
October 1986,
Hinyokika kiyo. Acta urologica Japonica,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
July 1991,
Hinyokika kiyo. Acta urologica Japonica,
S Inoue, and
S Shibata, and
A Okumura, and
T Tanaka, and
Y Onitsuka, and
T Yoshimura, and
A Aiko, and
Y Ikuta, and
K Fukuma, and
K Matsuura
March 1974,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
