-transparent.png){kind=logo}
Incubation of FT-207 with cytosol obtained from OKK cells but not from HEPM cells in vitro resulted in marked formation of the active metabolite, 5-FU. Degradation of 5-FU measured by FBA formation was very low in OKK cytosol but high in HEPM cytosol. High activity of 5-FU formation and low activity of 5-FU degradation in tumor cells might be responsible for increased 5-FU levels in the tumors of patients. Inhibition of OKK cell growth by FT-207 occurred in parallel with an appearance of 5-FU in the nucleus. We presume that a factor present in OKK cytosol is a soluble enzyme.
Related Publications
T Yoneda, and
T Ogawa, and
M Sakuda
April 1987,
Nihon Gan Chiryo Gakkai shi,
T Yoneda, and
T Ogawa, and
M Sakuda
July 1989,
Nihon Gan Chiryo Gakkai shi,
T Yoneda, and
T Ogawa, and
M Sakuda
December 1983,
Hiroshima journal of medical sciences,
T Yoneda, and
T Ogawa, and
M Sakuda
October 1971,
Gan no rinsho. Japan journal of cancer clinics,
T Yoneda, and
T Ogawa, and
M Sakuda
June 1975,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
T Yoneda, and
T Ogawa, and
M Sakuda
April 1992,
Anti-cancer drugs,
T Yoneda, and
T Ogawa, and
M Sakuda
November 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Yoneda, and
T Ogawa, and
M Sakuda
November 1974,
Nihon Gan Chiryo Gakkai shi,
T Yoneda, and
T Ogawa, and
M Sakuda
August 1984,
Nihon Gan Chiryo Gakkai shi,
T Yoneda, and
T Ogawa, and
M Sakuda
April 1994,
Chemical & pharmaceutical bulletin,
