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The effect of hypothermic preservation of the heart and lungs with a crystalloid solution was evaluated in 12 mongrel dogs receiving heart-lung allografts. Six animals served as controls and received an immediate heart-lung transplant. Six animals were in the experimental group and received a heart-lung transplant after 5 hours of preservation at 4 degrees C following perfusion of both organs with a crystalloid solution. Physiological function of the heart and lungs was studied for 20 hours after transplantation. While cardiac function was minimally depressed following preservation, pulmonary function testing demonstrated significantly greater increases in extravascular lung water in experimental animals, suggesting that an ischemic lung injury occurred with this preservation technique. The model allows for future evaluation of other methods of combined preservation of both the heart and lungs for transplantation.
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
January 1990,
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
January 1988,
Respiration; international review of thoracic diseases,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
September 1969,
The British journal of surgery,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
September 1974,
Transplantation proceedings,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
March 2024,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
January 1991,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
July 1967,
Laboratory investigation; a journal of technical methods and pathology,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
July 1989,
The Journal of thoracic and cardiovascular surgery,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
August 1983,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
T W Feeley, and
F G Mihm, and
T P Downing, and
A M Sadeghi, and
W A Baumgartner, and
B A Reitz, and
N E Shumway
January 1994,
Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma,
