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Effects of beta-naphthoflavone (beta NF) on the activity of hepatic microsomal aflatoxin B1 (AFB1)-4-hydroxylase - the cytochrome P-450-dependent enzyme system which catalyzes the metabolism of AFB1 to AFM1 - and on AFB1-induced in vivo hepatocarcinogenesis were investigated in weanling male Fischer rats. A single i.p. injection of beta NF in doses of 20 mg/kg and 150 mg/kg induced AFB1-4-hydroxylase 3- and 4-fold, respectively, 48 h post injection. Feeding of diet containing 0.01% beta NF for a period of 9-weeks induced AFB1-4-hydroxylase approximately 2-fold. AFB1, given by intubation in a dose of 25 micrograms five times/week for 8 weeks, produced 42 weeks later a 100% incidence of liver lesions (neoplastic foci, nodules or tumors), but feeding beta-NF in diet at a concentration of 0.015% for one week prior to and during the 8 weeks of AFB1 treatment inhibited AFB1 hepatocarcinogenesis by approximately 75%. These results are in accord with the suggestion that AFB1-4-hydroxylase induction may be associated with the inhibition of AFB1 carcinogenesis, possibly occurring as a consequence of accelerated detoxification of AFB1 via its conversion to AFM1.
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
February 1977,
Journal of the National Cancer Institute,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
July 1999,
Chemico-biological interactions,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
December 1988,
Zhonghua yi xue za zhi,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
March 1992,
Indian journal of experimental biology,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
June 1981,
British journal of cancer,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
January 1996,
Archives of toxicology,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
January 1989,
Virchows Archiv. B, Cell pathology including molecular pathology,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
March 1995,
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
November 1982,
Journal of dairy science,
H L Gurtoo, and
P L Koser, and
S K Bansal, and
H W Fox, and
S D Sharma, and
A I Mulhern, and
Z P Pavelic
May 1989,
Cancer letters,
