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The effect of subminimal inhibitory concentrations (subMICs) of six commonly used antibiotics on adherence of Neisseria gonorrhoeae to rabbit mesentery was studied. We found that, at 1/2 MIC, ampicillin, cefoxitin and penicillin G decreased adherence of gonococci by more than 65%, and erythromycin by approximately 40%; doxycycline and tetracycline had no appreciable effect. Results suggest that subMICs of some antibiotics could affect interactions of gonococci with some mammalian cells, more specifically adherence, a critical step in the pathogenesis of an infection.
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