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Effects of thyrotropin-releasing hormone (TRH) on pancreatic exocrine secretion were investigated in isolated and blood-perfused canine pancreas preparations. During constant intra-arterial infusion of secretin (0.03-0.05 units/min), concentrations of protein and bicarbonate in the pancreatic juice were measured before and after intra-arterial injection of TRH (0.1-10 ng). TRH did not produce any significant changes in the flow rate of pancreatic juice and in the rate of pancreatic blood flow. TRH caused a significant suppression of protein and bicarbonate output in a dose-dependent manner. At 10 ng of TRH, this suppression lasted about 20 min. From these data, it is suggested that TRH acts directly on both acinar and ductular cells of the pancreas and inhibits the secretions of digestive enzymes and bicarbonate.
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
December 1983,
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F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
January 1982,
Clinical and experimental pharmacology & physiology,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
April 1986,
Archives internationales de pharmacodynamie et de therapie,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
May 1982,
Archives internationales de pharmacodynamie et de therapie,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
November 1993,
Pancreas,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
April 1981,
Gastroenterology,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
January 2018,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
February 1985,
Archives internationales de pharmacodynamie et de therapie,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
March 1987,
The Journal of laboratory and clinical medicine,
F Yamagishi, and
F Iijima, and
K Iwatsuki, and
I Komiya, and
T Yamada, and
S Chiba
November 1999,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
