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A double blind, randomised, crossover placebo controlled trial of 5% acyclovir cream, applied topically five times a day for five days, was carried out in 45 patients with recurrent herpes labialis. These patients had a total of 72 episodes, 34 of which were treated with the 5% acyclovir cream and 38 with placebo cream. Treatment was begun by the patients as soon as possible after the onset of prodromal symptoms. There was no significant clinical benefit from treatment with acyclovir cream compared with placebo cream. The median healing times were nine days with acyclovir cream, 10 days with placebo cream, and 13 days when no treatment was given. The possibility that the 40% propylene glycol cream base alone has a therapeutic effect must therefore be considered.
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
July 1985,
British medical journal (Clinical research ed.),
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
September 1985,
British medical journal (Clinical research ed.),
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
January 1996,
BMJ (Clinical research ed.),
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
February 1990,
The Journal of infectious diseases,
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
June 2008,
Medizinische Monatsschrift fur Pharmazeuten,
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
April 1996,
BMJ (Clinical research ed.),
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
January 1987,
Acta stomatologica Croatica,
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
November 2000,
The Medical letter on drugs and therapeutics,
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
January 2000,
Acta dermato-venereologica,
M Shaw, and
M King, and
J M Best, and
J E Banatvala, and
J R Gibson, and
M R Klaber
September 1983,
The British journal of dermatology,
