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The cyclooxygenase and lipoxygenase pathways that produce prostaglandins (PGs) and hydroxyeicosatetraenoic acids (HETEs) were studied in inflamed rabbit cornea. A cryogenic lesion was induced and five days later the epithelium, stroma and endothelium were isolated and incubated with [1-14C]arachidonic acid. After lesioning, the arachidonic acid metabolites, thromboxane B2, PGF2 alpha and 6-keto-PGF1 alpha exhibited the greatest increase in the stroma. Lipoxygenase products were formed in the three layers also, although 12-HETE predominated. The correlation between the synthesis of these compounds and corneal injury is discussed.
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