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The locus encoding the human T lymphocyte cell surface antigen Leu-2 has been assigned to chromosome 2 with a DNA mapping panel derived from somatic cell hybrids. The two genomic components identified by a cDNA clone for Leu-2 segregated with human chromosome 2 in all 24 independent hybrid clones examined. The cosegregation of the Leu-2 and immunoglobulin kappa (IgK) loci in hybrids with spontaneous rearrangements of chromosome 2 is consistent with the possibility that the Leu-2 locus is on proximal human 2p near IgK. In the mouse, a locus for a T lymphocyte cell surface antigen with properties similar to Leu-2 is closely linked to the IgK locus on mouse chromosome 6. Hence the syntenic relationship of a gene implicated in T cell killing with the immunoglobulin kappa locus would then be conserved in the mouse and human genomes.
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
February 1985,
The Journal of experimental medicine,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
March 1985,
Cell,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
September 1983,
The Journal of experimental medicine,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
December 1984,
Proceedings of the National Academy of Sciences of the United States of America,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
September 1984,
Somatic cell and molecular genetics,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
April 1987,
Scandinavian journal of immunology,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
September 1984,
The Journal of experimental medicine,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
June 1984,
European journal of immunology,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
July 1984,
The Journal of experimental medicine,
G Bruns, and
P Kavathas, and
Y Shiloh, and
K Sakai, and
J Schwaber, and
S A Latt, and
L A Herzenberg
September 1985,
Journal of immunology (Baltimore, Md. : 1950),
