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The influence on the antibacterial activity of introducing a 6 alpha-methoxy group into carbenicillin, and various 6 alpha-substituents into sulbenicillin and piperacillin was examined. Further variations of the side chain aryl group were examined in the 6 alpha-methoxy substituted series. This led to the identification of disodium 6 beta-(D,L-2-carboxy-2-thien-3-ylacetamido)-6 alpha-methoxypenicillanate (5b) as a beta-lactamase stable derivative with useful activity against Enterobacteriaceae, and disodium 6 beta-[D-2-(4-aminophenyl)-2-sulfoacetamido]-6 alpha-methoxypenicillanate (6e) with slightly lower activity against the Enterobacteriaceae but more active against Pseudomonas aeruginosa.
G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
October 1986,
The Journal of antibiotics,
G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
February 1993,
The Journal of antibiotics,
G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
October 1986,
The Journal of antibiotics,
G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
February 1972,
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G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
December 1975,
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G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
January 1969,
Advances in applied microbiology,
G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
September 1968,
Journal of pharmaceutical sciences,
G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
April 1957,
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G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
December 1971,
Proceedings of the Royal Society of London. Series B, Biological sciences,
G Burton, and
M J Basker, and
P H Bentley, and
D J Best, and
R A Dixon, and
F P Harrington, and
R F Kenyon, and
A G Lashford, and
A W Taylor
December 1984,
The Journal of antibiotics,
