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The enantiomers of cis-5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin and its methyl ether have been synthesized. The compounds were tested for central dopamine (DA) receptor activity, by using biochemical and behavioral tests in rats. The (1R,2S)-(-) enantiomers of 1 and 2 are characterized as centrally acting DA-receptor agonists while the corresponding (1S,2R)-(+) enantiomers are characterized as centrally acting DA-receptor antagonists. Compounds (+)-1 and (+)-2 differ from classical neuroleptics in being able to increase DA synthesis rate in a wide dose range without reducing locomotor activity, suggesting a pronounced selectivity for DA autoreceptors. Also the (-) enantiomers seem to act preferentially on DA autoreceptors.
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
January 1990,
Proceedings of the Western Pharmacology Society,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
April 1986,
European journal of pharmacology,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
June 2020,
Molecular pharmaceutics,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
January 1976,
Arzneimittel-Forschung,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
May 1992,
European journal of pharmacology,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
August 1993,
European journal of pharmacology,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
January 1991,
Journal of neural transmission. General section,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
January 1988,
Advances in experimental medicine and biology,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
May 1979,
British journal of pharmacology,
A M Johansson, and
L E Arvidsson, and
U Hacksell, and
J L Nilsson, and
K Svensson, and
S Hjorth, and
D Clark, and
A Carlsson, and
D Sanchez, and
B Andersson
October 1989,
The Journal of pharmacology and experimental therapeutics,
