-transparent.png){kind=logo}
Fistulization of the membranous labyrinth via a surgically created endolymphatic-perilymphatic shunt (cochleosacculotomy) is currently being advocated as a treatment for endolymphatic hydrops. As a preliminary study to the investigation of the effects of labyrinthine fistulization on the hydropic condition, we sought first to reproduce the cochleosacculotomy procedure in a series of normal animals. Fistulization of the cochlear duct was performed in 15 normal animals using a tungsten wire directed via the round window through the cochlear partition in the region of the organ of Corti. The animals were sacrificed at regular intervals and the cochleas examined for histopathologic changes with the scanning electron microscope. Observations suggest that discrete permanent fistulization of the cochlear duct in the normal guinea pig results in progressive sensory cell degeneration. The implication of these observations and the apparent difference between these results and the experience thus far reported in humans are discussed.
E A Dimitrov, and
L G Duckert
January 1982,
The Annals of otology, rhinology, and laryngology,
E A Dimitrov, and
L G Duckert
August 1980,
Archivum histologicum Japonicum = Nihon soshikigaku kiroku,
E A Dimitrov, and
L G Duckert
October 1984,
Acta ophthalmologica,
E A Dimitrov, and
L G Duckert
June 1989,
Scanning microscopy,
E A Dimitrov, and
L G Duckert
August 1990,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
E A Dimitrov, and
L G Duckert
January 2016,
Neural plasticity,
E A Dimitrov, and
L G Duckert
January 1964,
Archivio di tisiologia e delle malattie dell'apparato respiratorio,
E A Dimitrov, and
L G Duckert
April 1976,
The Anatomical record,
E A Dimitrov, and
L G Duckert
August 1995,
British journal of audiology,
E A Dimitrov, and
L G Duckert
April 1989,
Chinese medical journal,
