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The role of corticotropin-releasing factor (CRF) in mediating the stress response was studied using a behavioral test in which anxiety or conflict influence performance. Rats implanted with intraventricular cannulae were tested in a Geller-Seifter conflict test modified for incremental shock. CRF produced a dose-dependent attenuation of punished and nonpunished responding in the conflict test. Chlordiazepoxide increased punished, but not unpunished, responding and produced a dose-dependent reversal of CRF-induced response suppression. CRF had no effect on tail flick or hot-plate analgesia tests. The results support the hypothesis that CRF produces behavioral effects consistent with "anxiety" or an increased responsiveness to stress.
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
October 1993,
Brain research,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
January 1986,
Psychopharmacology,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
January 1995,
Behavioural pharmacology,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
September 1995,
Brain research. Molecular brain research,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
August 1984,
The New England journal of medicine,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
March 1986,
Nihon rinsho. Japanese journal of clinical medicine,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
September 2001,
European journal of pharmacology,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
January 1984,
Lancet (London, England),
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
March 2002,
Biological psychiatry,
K T Britton, and
J Morgan, and
J Rivier, and
W Vale, and
G F Koob
September 1989,
The American journal of physiology,
