BIOMAT Database Logo BIOMAT Database Logo

Comparison of the effect of three oral mucolytics on the ultrastructure of the tracheal epithelium in rabbits. 1985

V Konrádová, and V Vávrová, and J Sulová

The effect of the application of a single oral dose of 100 mg of three mucolytic agents (N-acetylcysteine, carbocysteine and Na-2-mercaptoethane sulphonate) on the ultrastructure of the tracheal epithelium of healthy rabbits was studied. Due to the function of oral mucolytics the goblet cells were overstimulated and injured. Na-2-mercaptoethane sulphonate was the least irritating substance. Acetylcysteine produced the most pronounced injury of the goblet cells, followed by rapid differentiation of these cells. Oral administration of all mucolytics studied caused local impairment of mucus flow in the airways.

UI MeSH Term Description Entries
D008623 Mercaptoethanol A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation. 2-ME,2-Mercaptoethanol,2 Mercaptoethanol
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002233 Carbocysteine A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action. 3-(Carboxymethylthio)alanine,Carbocysteine, L-Isomer,Mucodine,Mucodyne,Mukodin,Rhinathiol,S-(Carboxymethyl)-L-cysteine,S-Carboxymethylcysteine,Thiodril,Carbocysteine, L Isomer,L-Isomer Carbocysteine,S Carboxymethylcysteine
D004848 Epithelium The layers of EPITHELIAL CELLS which cover the inner and outer surfaces of the cutaneous, mucus, and serous tissues and glands of the body. Mesothelium,Epithelial Tissue,Mesothelial Tissue,Epithelial Tissues,Mesothelial Tissues,Tissue, Epithelial,Tissue, Mesothelial,Tissues, Epithelial,Tissues, Mesothelial
D005100 Expectorants Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. Expectorant,Mucolytic,Mucolytic Agent,Mucolytic Agents,Mucolytics,Agent, Mucolytic,Agents, Mucolytic
D000111 Acetylcysteine The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates. Mercapturic Acid,Acemuc,Acetabs,Acetylcystein AL,Acetylcystein Atid,Acetylcystein Heumann,Acetylcystein Trom,Acetylcysteine Hydrochloride,Acetylcysteine Sodium,Acetylcysteine Zinc,Acetylcysteine, (D)-Isomer,Acetylcysteine, (DL)-Isomer,Acetylcysteine, Monoammonium Salt,Acetylcysteine, Monosodium Salt,Acetylin,Acetyst,Acétylcystéine GNR,Airbron,Alveolex,Azubronchin,Bisolvon NAC,Bromuc,Broncho-Fips,Broncholysin,Broncoclar,Codotussyl,Cystamucil,Dampo Mucopect,Eurespiran,Exomuc,Fabrol,Fluimucil,Fluprowit,Frekatuss,Genac,Hoestil,Ilube,Jenacystein,Jenapharm,Lantamed,Larylin NAC,Lindocetyl,M-Pectil,Muciteran,Muco Sanigen,Mucomyst,Mucosil,Mucosol,Mucosolvin,N-Acetyl-L-cysteine,N-Acetylcysteine,NAC AL,NAC Zambon,Optipect Hustengetränk,Siccoral,Siran,Solmucol,acebraus,durabronchal,mentopin Acetylcystein,Acetylcystein, mentopin,Acid, Mercapturic,Broncho Fips,BronchoFips,Hustengetränk, Optipect,Hydrochloride, Acetylcysteine,M Pectil,MPectil,Monoammonium Salt Acetylcysteine,Monosodium Salt Acetylcysteine,Mucopect, Dampo,N Acetyl L cysteine,N Acetylcysteine,NAC, Bisolvon,Sanigen, Muco,Sodium, Acetylcysteine,Zambon, NAC,Zinc, Acetylcysteine
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014132 Trachea The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Tracheas

Related Publications

V Konrádová, and V Vávrová, and J Sulová
Effect of bronchoalveolar lavage on the ultrastructure of the tracheal epithelium in rabbits.
January 1990, Respiration; international review of thoracic diseases,
V Konrádová, and V Vávrová, and J Sulová
Ultrastructure of the tracheal epithelium in rabbits after acetylcholine administration.
January 1996, Folia biologica,
V Konrádová, and V Vávrová, and J Sulová
Effects of 90% oxygen exposure on the ultrastructure of the tracheal epithelium in rabbits.
January 1988, Respiration; international review of thoracic diseases,
V Konrádová, and V Vávrová, and J Sulová
Ultrastructure of the mouse tracheal epithelium.
June 1969, Journal of morphology,
V Konrádová, and V Vávrová, and J Sulová
Ultrastructure of rat tracheal epithelium.
January 1979, Lung,
V Konrádová, and V Vávrová, and J Sulová
[Ultrastructure of the tracheal epithelium in children].
January 1967, Ceskoslovenska pediatrie,
V Konrádová, and V Vávrová, and J Sulová
Comparison of the effect of a high and low dose of atropin on the ultrastructure of the tracheal epithelium.
January 1996, Respiration; international review of thoracic diseases,
V Konrádová, and V Vávrová, and J Sulová
The ultrastructure of tracheal epithelium in the fowl.
July 1971, Research in veterinary science,
V Konrádová, and V Vávrová, and J Sulová
The ultrastructure of the tracheal epithelium in rabbit.
January 1966, Folia morphologica,
V Konrádová, and V Vávrová, and J Sulová
The effect of a single oral administration of ambroxol on the ultrastructure of the epithelium of terminal bronchioles in rabbits.
January 2001, Sbornik lekarsky,
Copied contents to your clipboard!