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The usefulness of radionuclide imaging studies with 99m-technetium diethylenetriaminepentaacetic acid (Tc-DTPA) for quantitating the glomerular filtration rate (GFR) in children was studied. This was compared to the conventional methods for measuring GFR using 51-chromium-EDTA clearance (Cr-EDTA), creatinine clearance and a height/plasma creatinine formula. In the 22 children studied, the correlation coefficient between renal uptake of DTPA and Cr-EDTA was 0.90 (p less than 0.001). In contrast, there was a poorer correlation between Cr-EDTA and creatinine clearance (r = 0.69) or the derived GFR using height/creatinine formula (r = 0.83). The regression line between Tc-DTPA uptake and Cr-EDTA clearance was used to derive a formula for calculating the predicted GFR. This was tested in 10 additional children, and the correlation between the predicted GFR and measured GFR (using Cr-EDTA clearance studies) was 0.92 (p less than 0.001). Quantitative estimation of the GFR during renal imaging studies is a feasible and convenient method of assessing renal function.
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
January 1991,
European journal of nuclear medicine,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
June 1988,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
March 1987,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
November 1985,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
June 1998,
Nuklearmedizin. Nuclear medicine,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
December 1969,
Acta radiologica: therapy, physics, biology,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
September 1986,
Clinical nuclear medicine,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
April 1990,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
June 1972,
Revista clinica espanola,
H K Yap, and
F X Sundram, and
W C Yip, and
J S Tay, and
E S Ang, and
H J Toh, and
V T Joseph, and
A H Saw
August 1972,
Archives of disease in childhood,
