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Reaction conditions which promote the heme-dependent peroxidase activity of prostaglandin H synthase appear to stimulate the heme-dependent cyclooxygenase activity also present in the synthase, even though the cyclooxygenase requires hydroperoxide for activity. However, aspirin-treated synthase, which retains only peroxidase activity, inhibited the cyclooxygenase activity of untreated synthase in the manner observed with similar levels of glutathione peroxidase. Any stimulatory effect of the synthase peroxidase on the synthase cyclooxygenase is thus likely to involve an intramolecular mechanism. Participation of peroxidase intermediates (Compounds I and II) in the initiation of a cyclooxygenase free radical chain reaction may provide an intramolecular mechanism for stimulation of the synthase cyclooxygenase by the synthase peroxidase.
R J Kulmacz, and
J F Miller, and
W E Lands
January 1990,
Methods in enzymology,
R J Kulmacz, and
J F Miller, and
W E Lands
October 1989,
Bioorganicheskaia khimiia,
R J Kulmacz, and
J F Miller, and
W E Lands
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
R J Kulmacz, and
J F Miller, and
W E Lands
October 2002,
European journal of pharmacology,
R J Kulmacz, and
J F Miller, and
W E Lands
April 1993,
The Journal of biological chemistry,
R J Kulmacz, and
J F Miller, and
W E Lands
January 1992,
Pharmacology & therapeutics,
R J Kulmacz, and
J F Miller, and
W E Lands
October 2001,
Circulation research,
R J Kulmacz, and
J F Miller, and
W E Lands
January 1990,
Annual review of pharmacology and toxicology,
R J Kulmacz, and
J F Miller, and
W E Lands
January 1991,
Histochemistry,
R J Kulmacz, and
J F Miller, and
W E Lands
August 1954,
Archives of biochemistry and biophysics,
