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In vitro inhibition of rat liver mitochondrial and microsomal aldehyde dehydrogenase (ALDH) under conditions of active CCl4 metabolism was investigated. Incubation of microsomes or mitochondria in the presence of NADPH alone caused significant, time-dependent inhibition of mitochondrial and microsomal ALDH. EDTA partially protected ALDH from inhibition. Incubation of microsomes or microsomes plus mitochondria in the presence of NADPH and CCl4 resulted in marked inhibition of microsomal and mitochondrial ALDH activity. The inhibition was both dose- and time-dependent and was relatively less in the presence of EDTA. It is proposed that the inhibition of membrane-bound ALDH may be one of the early events responsible for the genesis of CCl4-hepatotoxicity.
M F Kenel, and
A P Kulkarni
February 2010,
Free radical biology & medicine,
M F Kenel, and
A P Kulkarni
December 1981,
The Journal of pharmacology and experimental therapeutics,
M F Kenel, and
A P Kulkarni
June 1981,
Toxicology and applied pharmacology,
M F Kenel, and
A P Kulkarni
March 1951,
The Journal of pharmacy and pharmacology,
M F Kenel, and
A P Kulkarni
January 2001,
Chemico-biological interactions,
M F Kenel, and
A P Kulkarni
February 1983,
Toxicology and applied pharmacology,
M F Kenel, and
A P Kulkarni
December 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M F Kenel, and
A P Kulkarni
March 1987,
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence,
M F Kenel, and
A P Kulkarni
June 1978,
Research communications in chemical pathology and pharmacology,
M F Kenel, and
A P Kulkarni
April 1983,
Canadian journal of physiology and pharmacology,
