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Pulsatile substitution with GnRH appears to be the therapy of choice in patients with Kallmann's syndrome, a well defined type of hypogonadotropic hypogonadism. We tried to simplify the treatment and to limit the subcutaneous GnRH therapy to the period absolutely necessary to induce spermatogenesis. Therefore we applied in sequence first hCG to stimulate testicular growth and second pulsatile GnRH application to induce spermatogenesis. We herein report that with this mode of therapy testicular growth from infantile to adult size and normal spermatogenesis could be achieved. We conclude that pulsatile GnRH application is a new effective therapy of hypogonadotropic hypogonadism which can be simplified considerably by pretreatment with hCG.
D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
July 1984,
Experimental and clinical endocrinology,
D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
January 1988,
Acta endocrinologica. Supplementum,
D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
December 1991,
Nederlands tijdschrift voor geneeskunde,
D Klingmüller, and
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L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
April 2006,
Nihon rinsho. Japanese journal of clinical medicine,
D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
February 2023,
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D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
January 2017,
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D Klingmüller, and
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L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
November 1991,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
July 1987,
Journal of reproduction and fertility,
D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
October 1982,
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D Klingmüller, and
D Menger, and
L Wildt, and
G Leyendecker, and
F Krück, and
H U Schweikert
October 1979,
The Journal of clinical endocrinology and metabolism,
