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The blood level of [14C]coenzyme Q10 and the redox levels of [14C]coenzyme Q10 in the liver and heart were measured after intravenous injection of [14C]coenzyme Q10 solubilized in multilamellar liposomes into guinea pigs. The blood level of radioactivity declined biexponentially with half-lives of 11.5 min and 15.6 h in the first and second phases, respectively. The levels of reduced [14C]coenzyme Q10 in the liver and heart reached 55.8 and 46.4%, respectively, of the labeled compound in the tissues at 30 min after the injection. Coenzyme Q10-reducing activity in cytosol, microsomes and mitochondria was also investigated. This activity was found in all the fractions. The total activity was the highest in the liver cytosol. Moreover, the results of experiments using a purified enzyme suggested that one of the coenzyme Q10-reducing enzymes was NAD(P)H: quinone oxidoreductase [EC 1.6.99.2, DT-diaphorase]. These results are discussed in relation to the protective effect of reduced coenzyme Q10 against lipid peroxidation in membranes.
M Takada, and
T Yuzuriha, and
C Yamato
April 1984,
Nihon Kyobu Shikkan Gakkai zasshi,
M Takada, and
T Yuzuriha, and
C Yamato
June 1964,
Biochemische Zeitschrift,
M Takada, and
T Yuzuriha, and
C Yamato
January 1978,
Biochemical Society transactions,
M Takada, and
T Yuzuriha, and
C Yamato
January 1981,
Voprosy meditsinskoi khimii,
M Takada, and
T Yuzuriha, and
C Yamato
January 1971,
Pflugers Archiv : European journal of physiology,
M Takada, and
T Yuzuriha, and
C Yamato
January 2004,
BioFactors (Oxford, England),
M Takada, and
T Yuzuriha, and
C Yamato
September 1986,
The Journal of pharmacy and pharmacology,
M Takada, and
T Yuzuriha, and
C Yamato
June 1979,
Clinica chimica acta; international journal of clinical chemistry,
M Takada, and
T Yuzuriha, and
C Yamato
December 1964,
Bollettino della Societa italiana di biologia sperimentale,
M Takada, and
T Yuzuriha, and
C Yamato
January 1984,
Life sciences,
