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The effect of a single sc injection of an LRH antagonist ((Ac-D-p-Cl-Phe1,2,D-Trp3,D-Phe6,D-Ala10)-LRH, Org 30093) into OVX rats on FSH release 24 h later was studied. Plasma FSH was decreased but pituitary FSH content was not changed. Incubation of the pituitary glands during 4 h resulted in a decreased basal release. FSH release induced by a low concentration of LRH (1 ng/ml) was depressed but that of a high concentration (10 000 ng/ml) was augmented in comparison to FSH release induced in control glands. However, pretreatment with the antagonist had no specific effect on FSH release in vitro induced by high K+ or high K+ plus mbcAMP and theophylline, indicating that the changes of pituitary responsiveness to LRH are not caused by those parts of the secretory mechanism which are stimulated by these secretagogues. Moreover, it is concluded that the changes of pituitary LH release induced by administration of an LRH antagonist also concern FSH.
J A van Dieten, and
G P van Rees
September 1986,
Acta endocrinologica,
J A van Dieten, and
G P van Rees
February 1982,
Acta endocrinologica,
J A van Dieten, and
G P van Rees
January 2002,
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit,
J A van Dieten, and
G P van Rees
November 1985,
Acta endocrinologica,
J A van Dieten, and
G P van Rees
January 2006,
Neuro endocrinology letters,
J A van Dieten, and
G P van Rees
January 1978,
Neuroendocrinology,
J A van Dieten, and
G P van Rees
February 1982,
Acta endocrinologica,
J A van Dieten, and
G P van Rees
January 1996,
Yao xue xue bao = Acta pharmaceutica Sinica,
J A van Dieten, and
G P van Rees
January 2012,
Biomedical sciences instrumentation,
J A van Dieten, and
G P van Rees
January 1992,
Bone,
