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We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. The inhibitor was transient and behaved like a low titre, type II factor VIII procoagulant inhibitor similar to previously reported cases (Biggs et al, 1972b). In vitro studies confirmed the type II-like interaction of this inhibitor with the factor VIII procoagulant molecule. Factor VIII procoagulant antigen level was equal to the factor VIII procoagulant activity, which excluded dysproteinaemia as the cause. This patient's HLA type has no known association with abnormal immune responsiveness or autoimmune disease, and his clinical course as well as in vitro studies were similar to the eight previously reported cases of factor VIII procoagulant inhibitors arising in mild haemophilia A.
E G Bovill, and
S L Burns, and
E A Golden
December 1975,
Haematologica,
E G Bovill, and
S L Burns, and
E A Golden
April 1986,
British journal of haematology,
E G Bovill, and
S L Burns, and
E A Golden
August 1984,
Thrombosis and haemostasis,
E G Bovill, and
S L Burns, and
E A Golden
February 1985,
Thrombosis and haemostasis,
E G Bovill, and
S L Burns, and
E A Golden
August 2004,
Thrombosis and haemostasis,
E G Bovill, and
S L Burns, and
E A Golden
July 1998,
Haemophilia : the official journal of the World Federation of Hemophilia,
E G Bovill, and
S L Burns, and
E A Golden
November 2006,
Haemophilia : the official journal of the World Federation of Hemophilia,
E G Bovill, and
S L Burns, and
E A Golden
March 2001,
Haemophilia : the official journal of the World Federation of Hemophilia,
E G Bovill, and
S L Burns, and
E A Golden
January 1983,
Clinical and laboratory haematology,
E G Bovill, and
S L Burns, and
E A Golden
September 2013,
Haemophilia : the official journal of the World Federation of Hemophilia,
