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A study with valproic acid (VPA) was performed in Sprague-Dawley rats with the aim of relating drug serum levels to variations of leukocytes, platelets, coagulation time and other haematological parameters. VPA, 20 and 240 mg/kg, were administered orally, three times a day in groups of rats of both sexes throughout 7, 14, 30, 60 and 90 day periods. Total blood leukocytes averaged 7296 +/- 443 in control as well as in treated groups. Lymphocytes and monocytes decreased in all five groups when receiving the TD50 of 240 mg/kg (P less than 0.05). The VPA fasting serum levels were detectable if administered at 8 hr intervals. Nevertheless, VPA caused modification of the chosen parameters. VPA t1/2 averaged 3 hr in rats. Thus, even if the VPA effects were observed in our experiments, we suggest dividing the whole VPA dose into eight portions to be administered at 3 hr intervals in rats to attain constant serum VPA levels as well as constant drug effects.
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
October 1988,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
January 1991,
Toxicology in vitro : an international journal published in association with BIBRA,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
January 2006,
In vivo (Athens, Greece),
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
November 1987,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
October 2018,
Biomedical and environmental sciences : BES,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
November 2011,
Bulletin of experimental biology and medicine,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
January 1993,
Archiv der Pharmazie,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
March 1996,
Toxicology letters,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
December 2021,
Artificial cells, nanomedicine, and biotechnology,
C Almodovar-Cuevas, and
A Navarro-Ruiz, and
B E Bastidas-Ramírez, and
M R Mora-Navarro, and
P Garzón
January 1997,
Reproductive toxicology (Elmsford, N.Y.),
