-transparent.png){kind=logo}
Intravenous administration of PPD into BCG-primed rabbits results in the release of IFN into the circulation. Peak interferon titres occur in plasma 1 h after PPD injection, rapidly decline during the following 3 h and depend on the dose of tuberculin administered. Bilateral nephrectomy of BCG-primed rabbits challenged with PPD affects remarkably the disappearance of IFN from the circulation. Characterization of the BCG-PPD-induced IFN shows that it is heat-labile, is almost completely inactivated after dialysis at pH 2 and displays a remarkable cross-species activity, particularly on human cell lines.
Related Publications
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
April 1984,
Cellular immunology,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
September 1983,
Cellular immunology,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
April 1986,
The Journal of antibiotics,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
November 1976,
Journal of immunology (Baltimore, Md. : 1950),
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
October 1971,
Gruzlica i choroby pluc; tuberculosis et pneumonologia,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
January 1986,
Ciba Foundation symposium,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
March 1973,
Gruzlica i choroby pluc; tuberculosis et pneumonologia,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
October 1971,
Gruzlica i choroby pluc; tuberculosis et pneumonologia,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
January 1971,
Pathologia et microbiologia,
G P Pessina, and
L Paulesu, and
M Muscettola, and
S Skiftas, and
G Lunghetti, and
V Bocci
September 1964,
Acta tuberculosea Japonica,
