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Lymphocyte blast transformation responses to mitogens and to streptococcal, adenovirus Type 1, and oral mucosal antigens were studied in 32 patients with recurrent aphthous ulceration (RAU) and matched control subjects. RAU patients showed significantly depressed (p less than 0.05) responses to mitogens in comparison with matched controls, but there was no significant difference between patients and controls in response to any of the antigens tested. These results indicate that neither cell-mediated hypersensitivity to streptococcal or viral antigens nor cross-reactivity between oral mucosal and streptococcal antigens are likely to play a role in the pathogenesis of RAU. Rather, the data support the hypothesis of an imbalance or defect in immune cell subpopulations.
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
August 1991,
Acta odontologica Scandinavica,
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
January 1989,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
October 1976,
International journal of dermatology,
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
August 1987,
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology,
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
April 1992,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
November 1964,
Lancet (London, England),
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
January 1985,
Journal (Indiana Dental Association),
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
May 2001,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
April 1978,
British medical journal,
J S Greenspan, and
N Gadol, and
J A Olson, and
C I Hoover, and
P L Jacobsen, and
E J Shillitoe, and
G C Armitage
February 1989,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
