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To examine the bioavailability of nitroglycerin in sublingual tablet, 5 healthy adult volunteers underwent simultaneous sublingual administration of a tablet prepared with methylcellulose and a tablet prepared with lactose containing 0.15 mg of nitroglycerin and 0.15 mg of nitroglycerin-15N3, respectively. In 4 of 5 volunteers, no difference in plasma concentration determined by gas chromatography-mass spectrometry (GC-MS) was observed between 2 tablets described above, so it was well accepted that nitroglycerin in tablets prepared with methylcellulose had a similar bioavailability to that in tablets prepared with lactose. The simultaneous administration of the 2 nitroglycerin tablets to a healthy volunteer, one of which containing the drug labeled with a stable isotope followed by GC-MS assay, seems to be the most suitable method for a precise comparison of bioavailability of the formulations.
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
June 2020,
International journal of pharmaceutics,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
January 1974,
Farmatsiia,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
May 2024,
International journal of pharmaceutics,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
April 2010,
Drug discoveries & therapeutics,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
January 1973,
Arzneimittel-Forschung,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
September 2019,
AAPS PharmSciTech,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
December 2016,
Carbohydrate polymers,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
November 2023,
International journal of pharmaceutics,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
February 2008,
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,
F Shibuya, and
K Kuramoto, and
H Koizumi, and
N Uehara, and
F Nakagawa, and
Z Tamura, and
M Murayama, and
K Kawakubo, and
T Kawahara, and
M Ohshiro
September 2004,
Die Pharmazie,
