-transparent.png){kind=logo}
To study current situation of pathogenic bacteria and their drug resistance to macrolide antibiotics in the otorhinolaryngological infections, 609 strains diagnosed as pathogen derived from 463 patients were collected from cohospitals or institutions during the period of 1980-1983. The results obtained were as follows: Gram-positive cocci (GPC) was dominant (410 strains) and major species were S. aureus (135 strains), S. pneumoniae (81 strains), S. epidermidis (68 strains) and S. pyogenes (65 strains). In Gram-negative bacteria giving 147 strains and 43 strains, of anaerobes prevailing species were H. influenzae, P. aeruginosa and Peptostreptococcus spp. Representative species in the diseases were S. aureus (26.6%), S. epidermidis (24.5%), and P. aeruginosa (12.8%) in acute otitis media, S. aureus (34.4%), S. epidermidis (17.7%) and P. aeruginosa (14.6%) in acute exacerbation of chronic otitis media, S. epidermidis (17.0%), S. aureus (16.1%) and H. influenzae (13.4%) in acute paranasal sinusitis, S. pyogenes (29.1%), S. pneumoniae (19.6%) and S. aureus (15.1%) in acute tonsillitis. Although most of isolates were susceptible to macrolides, 62 resistant strains to macrolides were found in 501 strains and the resistant rates were 26.7% in S. aureus, 23.1% in S. epidermidis and 6.5% in S. pyogenes. The resistant pattern was somewhat different against each macrolides, resistant strains giving over 100 micrograms/ml in MIC were 55/62 in erythromycin, 35/62 in josamycin and midecamycin and 7/62 in TMS-19-Q, a new macrolide.
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
December 1990,
The Japanese journal of antibiotics,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
January 1983,
The Journal of antimicrobial chemotherapy,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
February 2006,
The Japanese journal of antibiotics,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
February 2009,
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
November 1963,
Antibiotiki,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
November 2012,
The Journal of infection,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
January 2006,
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
February 1987,
The British journal of oral & maxillofacial surgery,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
July 1989,
Mikrobiyoloji bulteni,
S Baba, and
H Kinoshita, and
Y Mori, and
K Suzuki, and
J Shimada, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
S Ogura
October 1985,
The Japanese journal of antibiotics,
