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In 8 patients with hypothalamic primary amenorrhea aged from 16 to 23 years (average age 19,4 years) a sequential stimulations test was performed with 0,5 g arginine hydrochloride per kg body weight, 25 micrograms gonadotropin-releasing hormone (GnRH) and 200 micrograms thyreotropin-releasing hormone (TRH). The response of the lactotropic, gonadotropic, thyreotropic and somatotropic cells of the pituitary was investigated. Serum levels of PRL, LH, FSH, TSH and HGH were determined by RIA. In all women hypoplastic ovaries were found by laparoscopy. In 7 patients tissue biopsies showed primordial follicles or primordial and secondary follicles, respectively. Investigations point to, that in hypothalamic primary amenorrhea at first the function of the gonadotropic and lactotropic cells of the pituitary is injured. The somatotropic cells could not be stimulated in 3 of 8 patients, the function of hypothalamo-pituitary-thyroid-axis in the stimulations test was normal in all women.
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
January 1988,
Acta Europaea fertilitatis,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
January 1991,
Acta Europaea fertilitatis,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
January 1989,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
January 1988,
Zentralblatt fur Gynakologie,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
May 1993,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
April 1988,
The Journal of clinical endocrinology and metabolism,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
January 1990,
Annales d'endocrinologie,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
January 1969,
Bulletin de l'Academie nationale de medecine,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
March 2021,
The Journal of clinical endocrinology and metabolism,
K Rudolf, and
S Kunkel, and
R Sudik, and
M Rüting, and
E Rohde
January 1975,
Annali dell'Ospedale Maria Vittoria di Torino,
