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A highly virulent strain of Salmonella tyhimurium was given orally to produce disease experimentally in 21 normal colostrum-fed calves 3 to 9 weeks old. The challenge inoculum varied from 10(4) to 10(11) organisms. The disease was characterized by fever, depressed attitude, and decreased appetite. Many calves given larger challenge dose levels also had diarrheic feces containing mucus, fibrin, and blood. Fecal cultures were positive for salmonella. Septicemia occurred in some calves (9 of 15 calves cultured were positive). Eleven calves died and 10 calves survived challenge exposure. Survival was inversely related to the size of the challenge inoculum and directly related (although to a lesser degree) to age of the calf. White blood cell total and differential counts were variable. Both neutropenia and neutrophilia were observed. Plasma proteins decreased markedly in calves with diarrhea, probably indicating fecal protein loss. Fibrinogen increased during the acute stages of diarrhea.
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
January 1991,
Vaccine,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
April 1976,
The Veterinary record,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
May 2014,
Veterinary microbiology,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
September 1978,
Research in veterinary science,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
May 1966,
The Veterinary record,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
September 1978,
Lancet (London, England),
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
November 1988,
The Veterinary record,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
February 1998,
Vaccine,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
March 2010,
Veterinary pathology,
B P Smith, and
F Habasha, and
M Reina-Guerra, and
A J Hardy
March 2002,
Veterinary pathology,
