Biomaterial Database

Acute toxicity and primary irritancy of 2-amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine. 1985

B Ballantyne

2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and intravenously, ACCPE was significantly less acutely toxic than CS. Also, whilst CS was a moderate dermal and eye irritant, ACCPE was not a primary skin irritant and only marginally irritating to the eye. ACCPE presents a significantly lower acute handling hazard than does CS.

UI	MeSH Term	Description	Entries
D007275	Injections, Intravenous	Injections made into a vein for therapeutic or experimental purposes.	Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297	Male		Males
D009763	o-Chlorobenzylidenemalonitrile	A riot control agent which causes temporary irritation of the eyes and the mucosal surface of the respiratory tract. It is a more potent irritant than OMEGA-CHLOROACETOPHENONE, but less incapacitating.	o-Chlorobenzylidene Malonitrile,ortho-Chlorobenzylidenemalonitrile,2-Chlorobenzylidene Malonitrile,2-Chlorobenzylidenemalonitrile,CS Tear Gas,o-Chlorobenzylidene malonotrile,ortho-Chlorobenzylidene Malonitrile,2 Chlorobenzylidene Malonitrile,2 Chlorobenzylidenemalonitrile,Malonitrile, 2-Chlorobenzylidene,Malonitrile, o-Chlorobenzylidene,Malonitrile, ortho-Chlorobenzylidene,Tear Gas, CS,malonotrile, o-Chlorobenzylidene,o Chlorobenzylidene Malonitrile,o Chlorobenzylidene malonotrile,o Chlorobenzylidenemalonitrile,ortho Chlorobenzylidene Malonitrile,ortho Chlorobenzylidenemalonitrile
D011725	Pyridines	Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D005123	Eye	The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.	Eyes
D005260	Female		Females
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001706	Biopsy	Removal and pathologic examination of specimens from the living body.	Biopsies