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d-Amphetamine (20 mg) was administered intravenously in a double-blind design to 17 schizophrenic patients with and without concurrent 3-week lithium carbonate pretreatment to evaluate the lithium attenuation of d-amphetamine effects which we had observed in affective disorder patients. Lithium significantly attenuated the acute d-amphetamine-induced changes in an activation-euphoria cluster and in the mannerisms and posturing item of the Brief Psychiatric Rating Scale. Because the psychosis-increasing effects of d-amphetamine were not significantly decreased, it is conceivable that the d-amphetamine-induced changes in activation and euphoria and in psychosis are regulated by different dopamine mechanisms. The small clinical effects seen at 3 weeks of lithium treatment in schizophrenic patients could be mediated by dopamine.
D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
February 2015,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
March 2015,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
February 2004,
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D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
June 1996,
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D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
January 1995,
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D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
February 1997,
Pharmacology, biochemistry, and behavior,
D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
January 1986,
Psychopharmacology,
D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
May 1975,
The Western journal of medicine,
D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
January 1989,
Psychopharmacology,
D P van Kammen, and
J P Docherty, and
S R Marder, and
J E Rosenblatt, and
W E Bunney
January 1973,
The American journal of psychiatry,
