Biomaterial Database

Effects of chlorinated diphenyl ethers on the mixed-function oxidases and ultrastructure of rat and trout liver. 1985

Y C Chui, and M M Hansell, and R F Addison, and F C Law

The effects of chlorinated diphenyl ethers (CDEs) on hepatic mixed-function oxidase (MFO) activities and ultrastructure were examined in the rat and trout after ip administration of 100 mg/kg/day of 4-chlorodiphenyl ether (4-CDE), 2,4-dichlorodiphenyl ether (2,4-diCDE), 2,4,4'-trichlorodiphenyl ether (2,4,4'-triCDE), or 2,4,5,4'-tetrachlorodiphenyl ether (2,4,5,4'-tetraCDE) for 3 days. The 4-CDE, 2,4-diCDE, and 2,4,4'-triCDE pretreatments did not alter significantly the MFO activities of trout liver; however, 2,4,5,4'-tetraCDE pretreatment increased significantly the hepatic cytochrome b5 content and 7-ethoxycoumarin O-deethylase activity of trout liver. No histological changes were observed in the hepatocytes of trout treated with any of the CDEs. Pretreatment of rats with 4-CDE and 2,4-diCDE also did not alter significantly the MFO activities of the liver. In contrast, pretreatment of rats with 2,4,4'-triCDE and 2,4,5,4'-tetraCDE increased significantly hepatic MFO activities and also caused a proliferation of smooth endoplasmic reticulum in the liver. 2,4,4'-triCDE and 2,4,5,4'-tetraCDE appear to be a phenobarbital-type inducer and a mixed-type inducer of rat liver MFO activity, respectively.

UI	MeSH Term	Description	Entries
D007274	Injections, Intraperitoneal	Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.	Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010105	Oxygenases	Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.	Oxygenase
D011078	Polychlorinated Biphenyls	Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.	PCBs,Polychlorinated Biphenyl,Polychlorobiphenyl Compounds,Biphenyl, Polychlorinated,Biphenyls, Polychlorinated,Compounds, Polychlorobiphenyl
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D003573	Cytochrome b Group	Cytochromes (electron-transporting proteins) with protoheme (HEME B) as the prosthetic group.	Cytochromes Type b,Cytochromes, Heme b,Group, Cytochrome b,Heme b Cytochromes,Type b, Cytochromes,b Cytochromes, Heme,b Group, Cytochrome
D004790	Enzyme Induction	An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.	Induction, Enzyme