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A second example of chronic myeloid leukemia (CML) with the unusual simple variant t(22;22) is reported. In this case, break points are readily identified at bands q13 and q11. The nature of simple variant translocations in CML is discussed in the light of recent knowledge acquired from in situ hybridization of c-Ableson proto-oncogen DNA probes to metaphase spreads of CML patients.
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