-transparent.png){kind=logo}
The regiospecificity of arachidonic acid oxygenation, catalyzed by rat liver microsomal fractions in the presence of NADPH, can be altered by animal pretreatment with a fibric acid type of hypolipidemic drug, ciprofibrate. While microsomal fractions isolated from either control or phenobarbital-treated animals oxygenate arachidonic acid to mainly epoxyeicosatrienoic acids (EETs), animal pretreatment with ciprofibrate results in an eightfold stimulation of omega and omega-1 oxidation, concomitant with a net decrease in the formation of both HETEs and EETs. The isomeric composition of the EETs and of the omega and omega-1 oxidation products formed is also dependent on the type of animal pretreatment. Associated decreases in the amounts of HETEs and the rate of hydrogen peroxide formation suggests a modification of the "uncoupler action" of arachidonic acid during the function of different cytochromes P-450.
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
September 1981,
Proceedings of the National Academy of Sciences of the United States of America,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
April 1988,
The American journal of the medical sciences,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
January 1991,
Annual review of pharmacology and toxicology,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
July 1982,
Il Farmaco; edizione scientifica,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
August 1984,
Biochemical and biophysical research communications,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
January 1987,
Drug metabolism and disposition: the biological fate of chemicals,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
March 1988,
Archives of biochemistry and biophysics,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
August 1981,
Biochemical and biophysical research communications,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
August 1988,
Cancer research,
J Capdevila, and
Y R Kim, and
C Martin-Wixtrom, and
J R Falck, and
S Manna, and
R W Estabrook
August 1986,
The Biochemical journal,
