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High L-thyroxine (T4) and cortisol doses given to rats during the first 8 days of life and on the first day only respectively, produce decrease of body and brain weight and perturbances to brain energy substrates, i.e. glucose and ketone bodies. The same alterations are found in the undernourished rats from the prenatal period. The pituitary GH and TSH is decreased in the T4- and cortisol-injected animals. The plasma ACTH is decreased in the treated cortisol animals at 8, 12 and 22 days of life. The pituitary TSH content is reduced with respect to controls in the undernourished animals from 14 to 70 days of life. From the exposed experiments we suggest an alteration in the hypothalamic-pituitary complex in T4- and cortisol-treated rats, and describe the similarities between the three experimental models.
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
October 1976,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
October 1956,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
November 2019,
Nutrients,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
April 2004,
Indian journal of medical sciences,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
March 2004,
The British journal of nutrition,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
January 1971,
Developmental psychobiology,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
January 1969,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
February 2017,
Neuroscience,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
December 1974,
Journal of mental deficiency research,
A M Pascual-Leone, and
F Escrivá, and
C Alvarez, and
L Goya, and
C Rodriguez
August 1971,
Nutrition reviews,
