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A recently modified commercial enzyme immunoassay (Gonozyme; Abbott Laboratories, North Chicago, IL) for Neisseria gonorrhoeae antigens was compared with bacteriological culture for diagnostic sensitivity, specificity, and predictive value. A total of 480 specimens were tested by both methods; 355 from females attending a sexually transmitted disease clinic ("high-risk") and 125 from female Family Planning clients ("low-risk"). Sensitivity and specificity of enzyme immunoassay for sexually transmitted disease clinic specimens were 79.7 and 97.9%, respectively (55 positive, 280 negative, 6 false positive, 14 false negative). In the low-risk population, sensitivity and specificity were 100 and 97.5%, respectively (3 positive, 119 negative, 3 false positive, 0 false negative). Despite modification, sensitivity of the method remains low for our sexually transmitted disease clinic population, but the test may have applicability for preliminary screening in low-prevalence settings.
M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
October 1984,
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M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
May 1985,
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M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
July 1984,
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M R Skeels, and
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H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
March 1987,
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M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
March 1984,
Journal of clinical microbiology,
M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
December 1982,
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M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
December 1985,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
June 1999,
Journal of preventive and social medicine : JOPSOM : a bi-annual journal of the National Institute of Preventive and Social Medicine,
M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
January 1989,
Journal of immunoassay,
M R Skeels, and
B Matsuda, and
H Horton, and
J Sampson, and
G A Sawyer, and
J Mitchell
January 1982,
Sexually transmitted diseases,
