[Sensitivity of grey and beige Djungarian hamsters to the blastomogenic action of 7,12-dimethylbenz(a)anthracene and 3-methylcholanthrene]. 1985

O I Sokova, and O E Kulagina, and Iu N Solov'ev, and E E Pogosiants

Sensitivity of normal gray and mutant beige (pink-eyed dilution mutation) Djungarian hamsters to the carcinogenic activity of 7,12-dimethylbenz (a) anthracene (DMBA) and 3-methylcholanthrene (MC) was studied. No differences between these two groups of animals which were given pills with DMBA were revealed. At the same time the beige females were found to be more sensitive to MC than males and hamsters of wild (gray) colour. Among tumours induced both by DMBA and MC fibrosarcomas prevailed both in the gray and beige hamsters. Fibrous histiocytomas were detected only in the MC-infected hamsters. Epithelial tumours were found only in females.

UI MeSH Term Description Entries
D008297 Male Males
D008748 Methylcholanthrene A carcinogen that is often used in experimental cancer studies. 20-Methylcholanthrene,3-Methylcholanthrene,20 Methylcholanthrene,3 Methylcholanthrene
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D005260 Female Females
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D015127 9,10-Dimethyl-1,2-benzanthracene Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen. 7,12-Dimethylbenzanthracene,7,12-Dimethylbenz(a)anthracene,7,12 Dimethylbenzanthracene

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