Biomaterial Database

Vitamin E status in gold-thioglucose-treated obese mice: the influence of weight loss. 1985

M G Vandewoude, and L Van Gaal, and C Dalemans, and I De Leeuw

The influence of weight-loss and dietary vitamin E supplementation on plasma vitamin E status has been evaluated in Gold-thioglucose induced hypothalamic obese mice. They were submitted for two weeks to different dietary regimens: a normal energy-normal vitamin E diet (standard diet), a low energy-normal vitamin E diet (protein sparing modified fast (PSMF)-diet) and a no energy-no vitamin E diet (total starvation) respectively. Plasma vitamin E levels were significantly higher in the PSMF-treated group (P less than 0.01) but remained constant in the total fast group as compared to obese controls. Plasma vitamin E/cholesterol ratio (being increased (P less than 0.01) in PSMF-mice and decreased (P less than 0.01) in total fast mice) was strongly correlated with dietary vitamin E/fat ratio. These results suggest that dietary vitamin E supplementation can prevent plasma vitamin E to decrease during rapid weight-loss and that vitamin E/fat ratio is the main parameter to evaluate the dietary adequacy of vitamin E supplementation.

UI	MeSH Term	Description	Entries
D009765	Obesity	A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002149	Energy Intake	Total number of calories taken in daily whether ingested or by parenteral routes.	Caloric Intake,Calorie Intake,Intake, Calorie,Intake, Energy
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D004038	Diet, Reducing	A diet designed to cause an individual to lose weight.	Weight Loss Diet,Weight Reduction Diet,Diet, Weight Loss,Diet, Weight Reduction,Diets, Reducing,Diets, Weight Loss,Diets, Weight Reduction,Reducing Diet,Reducing Diets,Weight Loss Diets,Weight Reduction Diets
D004044	Dietary Proteins	Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.	Proteins, Dietary,Dietary Protein,Protein, Dietary
D005215	Fasting	Abstaining from FOOD.	Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D005260	Female		Females
D006046	Gold	A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
D006051	Aurothioglucose	A thioglucose derivative used as an antirheumatic and experimentally to produce obesity in animals.	Gold Thioglucose,Aureotan,Auromyose,Aurothioglucose, Sodium Salt, beta-D Isomer,Aurothioglucose, beta-D Isomer,Gold-50,Solganal,Solganal B Oleosum,Solganol,Thioglucosoaurate,Aurothioglucose, beta D Isomer,B Oleosum, Solganal,Gold 50,Gold50,Oleosum, Solganal B,Thioglucose, Gold,beta-D Isomer Aurothioglucose