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Seventy-seven consecutive patients with pauciarticular or polyarticular juvenile rheumatoid arthritis were randomized to treatment with either gold sodium thiomalate (GSTM) or D-penicillamine (PEN) in a parallel 50-week clinical trial. Adverse reactions were reported by or observed in 9 GSTM-treated and 15 PEN-treated patients. Of these, 5 and 7 respectively were withdrawn from the study. Most disease activity measurements were changed in favour of the GSTM group, compared with the PEN group, but significant differences between the treatment regimens were observed for only a few measurements. This possible advantage of GSTM with regard to efficacy was only seen in patients with the polyarticular disease type.
T K Kvien, and
H M Høyeraal, and
B Sandstad
January 1982,
The Journal of rheumatology. Supplement,
T K Kvien, and
H M Høyeraal, and
B Sandstad
February 1990,
Ryumachi. [Rheumatism],
T K Kvien, and
H M Høyeraal, and
B Sandstad
January 1987,
Acta medica Iugoslavica,
T K Kvien, and
H M Høyeraal, and
B Sandstad
January 1976,
Verhandlungen der Deutschen Gesellschaft fur Rheumatologie,
T K Kvien, and
H M Høyeraal, and
B Sandstad
December 1990,
Clinical rheumatology,
T K Kvien, and
H M Høyeraal, and
B Sandstad
January 1976,
Zeitschrift fur Rheumatologie,
T K Kvien, and
H M Høyeraal, and
B Sandstad
June 1988,
Arthritis and rheumatism,
T K Kvien, and
H M Høyeraal, and
B Sandstad
October 1983,
Annales de pediatrie,
T K Kvien, and
H M Høyeraal, and
B Sandstad
September 1984,
Arthritis and rheumatism,
T K Kvien, and
H M Høyeraal, and
B Sandstad
January 1982,
The Journal of rheumatology,
