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Altogether 25 patients were examined one month after subtotal resection of the thyroid for diffuse toxic goiter. A wide spectrum of the TSH to TRH reaction was detected. The nature of this reaction made it possible to single out 4 groups of patients with a progressively decreasing and even paradoxical response of TSH to TRH. There were no correlations between the nature of the TSH to TRH reaction and the patients' thyroid status in the pre- and postoperative period, time-period of disease and the expression of autoimmune processes. Profound changes in function of the pituitary-hypothalamo-thyroid system were found in most of the patients at the above mentioned time after operation.
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