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The capacity of Pyrazinamide (PZA) to prevent the selection of Rifampicin (RMP) resistant mutants was tested by the intravenous innoculation of 160 mice with 2 X 10(6) c.f.u. of M. tuberculosis, and two weeks later, the treatment of the mice either with 10 mg/kg/day RMP alone or with RMP + PZA 150 mg/kg/day. After three months of treatment, lungs and spleen were culture positive in respectively 95% and 90% of the mice treated with RMP alone and in 37% and 24% of the mice treated by RMP + PZA (p less than 10(-5). The strains isolated from lungs and spleen were resistant to Rifampicin in respectively 87% and 75% of the mice treated with RMP alone and in none of those treated with RMP + PZA.
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
January 2022,
PloS one,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
May 2021,
Bulletin of experimental biology and medicine,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
June 2015,
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
June 1998,
Lancet (London, England),
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
October 1991,
Enfermedades infecciosas y microbiologia clinica,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
March 1991,
Enfermedades infecciosas y microbiologia clinica,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
July 1970,
The Japanese journal of tuberculosis and chest diseases,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
August 2009,
Bioinformation,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
January 2017,
PloS one,
J Grosset, and
C Truffot-Pernot, and
S Poggi, and
H Lecoeur, and
C Chastang
August 1985,
Kekkaku : [Tuberculosis],
