-transparent.png){kind=logo}
Cultured mouse L1210 leukaemia cells treated with DL-2-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17), in the presence of micromolar concentrations of cadaverine, started to overproduce ornithine decarboxylase after an exposure of several weeks. The more than 60-fold excess of the enzyme protein in the drug-treated cells apparently resulted from a strikingly enhanced accumulation of mRNA for the enzyme associated with only a modest (about 2-fold) gene amplification.
Related Publications
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
March 1990,
The Journal of biological chemistry,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
May 1996,
Biochimica et biophysica acta,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
August 1988,
The Journal of biological chemistry,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
July 1999,
The Biochemical journal,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
February 1987,
The Biochemical journal,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
June 1997,
The Biochemical journal,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
April 1996,
Antimicrobial agents and chemotherapy,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
April 1990,
Cancer research,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
December 1983,
Experimental and molecular pathology,
L Alhonen-Hongisto, and
R Sinervirta, and
O A Jänne, and
J Jänne
September 1989,
Preventive medicine,
