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In this investigation we examined the osteoinductive potential of demineralized bone matrix derived from chronically diabetic (streptozotocin-induced) rats. Long-Evans rats (28-31 days) were made diabetic with a single injection of streptozotocin (65 mg/kg) and provided food and water ad lib for 2 months. Diaphyseal shafts of femurs and tibias removed from the diabetic rats and their sibling controls were dehydrated, pulverized, sieved to 74-420 micron particles, and demineralized. Matrix was then bioassayed for its ability to induce endochondral bone on day 11 following subcutaneous implantation over the thorax of Long-Evans rats. The resulting plaques of tissue were subjected to histological analysis, determination of alkaline phosphatase activity, and calcium content. Bone matrix derived from diabetic animals proved to be a significantly better inducer of endochondral bone than did control matrix.
R Landesman, and
A H Reddi
August 1992,
Experientia,
R Landesman, and
A H Reddi
May 1990,
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
R Landesman, and
A H Reddi
October 1991,
Acta orthopaedica Scandinavica,
R Landesman, and
A H Reddi
January 1999,
The International journal of adult orthodontics and orthognathic surgery,
R Landesman, and
A H Reddi
August 1996,
International journal of oral and maxillofacial surgery,
R Landesman, and
A H Reddi
March 2014,
Maxillofacial plastic and reconstructive surgery,
R Landesman, and
A H Reddi
June 1992,
Spine,
R Landesman, and
A H Reddi
January 2003,
Connective tissue research,
R Landesman, and
A H Reddi
January 2009,
Iranian endodontic journal,
R Landesman, and
A H Reddi
September 1988,
Collagen and related research,
