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The isolated perfused rat kidney (IPRK) releases kallikrein in urine and renin in perfusate. We have previously shown (Kidney Int 24: 58-65, 1983) and confirm here that kallikrein, as well as renin releases are influenced by changes in renal hemodynamics in this model: a rise in perfusion pressure (PP) from 80 to 98 mmHg increases renal perfusate flow (RPF) by 48 +/- 3 p. 100, inhibits renin release and stimulates kallikrein secretion to 234 +/- 84 p. 100 of control values (n = 8). Since the perfusate lacks angiotensinogen, we decided to study the effect on kallikrein of the reconstitution of the renin-angiotensin system in the IPRK by adding angiotensinogen + angiotensin converting enzyme (AG + ACE) to the perfusion medium. After AG + ACE, PP rose to 107 +/- 4 mmHg, RPF decreased by 82 +/- 3 p. 100 as a consequence of the vasoconstrictor effect of angiotensin II, and renin release was suppressed. Again kallikrein secretion was stimulated and increased to 333 +/- 153 p. 100 of control values (n = 4). It is concluded 1) that kallikrein release is influenced by changes in PP but not in RPF on the IPRK. 2) that reconstitution of the renin-angiotensin system by addition of AG + ACE to the perfusate leads to vasoconstriction, suppression of renin release and a marked increase in kallikrein secretion.
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
July 1983,
Kidney international,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
January 1991,
Nephron,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
January 1992,
Life sciences,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
January 1983,
Renal physiology,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
December 1975,
The Australian journal of experimental biology and medical science,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
October 1967,
The American journal of physiology,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
February 1973,
Circulation research,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
January 1970,
Review of surgery,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
March 1990,
Pflugers Archiv : European journal of physiology,
J Gardes, and
J Misumi, and
M F Gonzalez, and
F Alhenc-Gélas, and
P Corvol, and
J Ménard
January 1974,
British journal of pharmacology,
