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The use of the DNA inhibitors hydroxyurea (HU) and nalidixic acid (NAL) to elucidate patterns of DNA metabolism in AS-1 infected A. nidulans have led to several conclusions. First, HU and NAL at concentrations of 500 and 100 micrograms/ml, respectively, inhibited DNA synthesis in synchronized A. nidulans. Protein and chlorophyll synthesis remained essentially unchanged as did turbidity increases. Second, the complete burst size of the cyanophage AS-1 was severely affected by HU and NAL treatment and burst sizes of 8 and 2.6, respectively, were obtained. Third, inhibitor treatment of infected cultures caused a premature release of phage at 12 h instead of 16 h post infection. Finally, HU treatment of the host cell had no effect on the formation of PIL-DNA, whereas NAL pretreatment blocked its formation.
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
October 1976,
Archives of microbiology,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
June 1975,
Virology,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
January 1979,
Journal of bacteriology,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
January 1980,
Voprosy virusologii,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
April 1976,
Journal of bacteriology,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
January 1979,
Archives of virology,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
November 1976,
Molecular biology reports,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
March 1983,
European journal of biochemistry,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
January 1978,
Journal of virology,
H L Lee, and
G Cohn, and
J Blamire, and
R McGowan
January 1974,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
