-transparent.png){kind=logo}
A new experimental system is used to determine exact information concerning local drug disposition. Rabbit hind leg is perfused in situ using a single-pass technique, and outflow curves of drugs are analyzed using statistical moment theory. By the introduction of chromatographic concepts and the application of the well-stirred model to the local perfusion system, physiologically and/or physicochemically meaningful parameters are derived from the first three moments. Moreover, in the assessment, drug disposition is divided into elimination and distribution. The elimination process is also evaluated with respect to rate and extent. This system is used to elucidate the disposition characteristics of mitomycin C and its lipophilic derivative nonyloxycarbonyl mitomycin C.
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
April 1988,
Journal of pharmacokinetics and biopharmaceutics,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
April 1991,
The Journal of pharmacy and pharmacology,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
June 1988,
Journal of clinical pharmacology,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
January 1982,
Drug metabolism and disposition: the biological fate of chemicals,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
June 1991,
Pharmaceutical research,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
October 1998,
Journal of the American Veterinary Medical Association,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
December 1987,
Chemical & pharmaceutical bulletin,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
September 1985,
Analytical chemistry,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
October 1990,
Journal of pharmacokinetics and biopharmaceutics,
T Kakutani, and
K Yamaoka, and
M Hashida, and
H Sezaki
February 1987,
Pharmaceutical research,
